What's New

Nanotechnology

Research in nanotechnology is opening new fields of development and applications in many areas: materials science (nanostructured materials), medicine, biotechnology, genomics, manufacturing, computing, information technology and communications. Sonicators have become an important tool for hundreds of companies in these areas.

Many customers use a standard probe for their pilot programs and later scale up to larger volumes. The Flocell and Dual Horn have proven effective for production runs up to several gallons per minute. Misonix has several research papers to share with you with advice on optimizing your results.

ChIP Assay

Chromatin Immunoprecipitation (ChIP) has emerged as a powerful and useful technique in identifying specific binding locations of proteins on the genome of living cells. Essential to the success of the ChIP assay is the random fragmentation of chromatin to lengths less than 1,000 base pairs in order to obtain accurate and accessible antibody interactions. The Misonix Sonicator 4000 makes shearing chromatin quick and easy and dramatically improves the reproducibility of your ChIP experiments.

The Misonix Sonicator® 3000 features advanced design and programming to allow for finite control of power and time parameters so you can better optimize your sonication conditions. When it comes to Chromatin Immunoprecipitation, there are many factors that affect DNA shearing efficiency including cell line selection, sample volume, cross-linking fixation time, sample preparation and the most important being sonication conditions. Therefore it is vital that your Sonicator has the versatility to adjust to your specific ChIP assay conditions.

Contact us for lab protocols and application notes to assist your research.

Wire Die Cleaning

A major wire manufacturer in North Carolina had a problem with effectively cleaning wire dies. For many years they had been using the XL-2000 model and it worked well. The technician held the die in water and directed the hand-held probe at the center of the die. This method was very effective but labor intensive and time consuming.

Wire manufacturing is a very dirty process which requires a lot of water and grease. Exposure to water and grease is dangerous for any electrical device. The XL-2000 unit required regular service to clean and fix shorted-out components due to moisture in the air. A sonicator is a high voltage device and a wet environment is not recommended.

The company needed help. Cleaning dies was taking too much time and they were spending too much money on maintaining the equipment. Misonix analyzed the process and the work area. We devised a plan to water proof the generator and converter and customized a Sonicator with a Dual Horn and a rotating holder for the dies.

This enabled the manufacturer to clean 8 dies per minute rather than their manual process of only one per minute. In addition, we eliminated down time and costly repairs associated with the older process.

Custom Applications

Misonix has the ability to produce horns in many shapes and sizes to handle unique situations. For example, we have the 96P Horn with 96 individual tips which is capable of directly sonicating a 96-well microtiter plate.

Please contact us regarding your application and we can see if a custom probe may help.