Sonication is effective for many applications including:
- Protein Purification
- Solubilize compounds
- Virus isolation
- Vaccine manufacturing
Qsonica can assist in rapidly re-tooling workflows to aid in efforts to fight COVID-19.
Please contact us for help with your coronavirus application.
Virus Research and Ultrasonics
Sonication is a reproducible established method for sample preparation when lysing cells for the release of virus, viral proteins, DNA and RNA.
Virus related applications:
- Cell lysis to extract viruses
- DNA and RNA fragmentation
- Disperse virus clusters
Sonicators can be used for fast, reproducible sample preparation to extract viruses from tissue and cell culture prior to downstream analyzation of proteins, nucleic acids, etc. Ultrasonic processing can also be used to shear DNA and RNA for sequencing.
Cup Horns are ideal for sterile or pathogenic sample processing and enables multiple tubes to be processed at one time. Samples can be processed in sealed tubes or vials eliminating aerosols and cross contamination.
Vaccine Production and Drug Formulation with Ultrasonics
Sonicators are used in vaccine production to create nano-sized drug delivery platforms. Systems can be sized for use in R&D, lab scale as well as industrial scale production.
Sonication can be used to:
- Lyse virus or bacterial cells to release proteins, antigens, DNA/RNA, etc.
- Destroy or inactivate viruses and bacteria.
- Prepare nano-sized drug delivery systems.
- Increase bioavailability by forming nanoparticles, nanoemulsions and liposomes.
- Create homogeneous suspensions with ultrasonic dispersion and deagglomeration.
Production Scale Sonicator:
Publications and Protocols
Frequently Asked Questions
Tip Depth / Foaming Issue - Probes/tips must be submerged properly. If the tip is not submerged enough the sample will foam or bubble. If the tip is too deep it will not circulate the sample effectively. Both conditions will end up with poor results. Foaming often occurs with samples volumes below 1ml. Foaming can also be caused when the amplitude setting is too high.
Visit the FAQ section for answers to more questions about sonication.