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For international orders, including Canada and Mexico, please call 203.426.0101 or e-mail info@sonicator.com. At present, we can only accept online orders for United States delivery.

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Sonicator systems have a 7-10 business day lead time. Probes, tips and general accessories are shipped within 1-3 business days. Selecting an express shipping method does not decrease the lead time but will expedite the actual shipping time once the order leaves our facility. Please contact Customer Service at 203.426.0101 if you would like to check stock and receive a more accurate lead time. Thank you.

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Deliveries to CT and NY will be charged sales tax. If you are tax-exempt and do not wish to pay sales tax, please call us at 203.426.0101.
Tissue Homogenization Application
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Let us help you select the appropriate Sonicator model and accessory for your application. Call us at 203.426.0101 or
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Tissue Homogenization

Ultrasonic homogenizers make use of the ultrasonic waves generated by a piezoelectric crystal. When a certain voltage is applied to the crystal, the ultrasonic waves are transmitted through water or air, leading to cavitation which in turn leads to the generation of forces on nearby surfaces. These powerful forces homogenize tissues, breaking apart connective tissues , lysing cells, and releasing cellular contents which may then be purified and utilized in a wide range of downstream analyses.

At Qsonica, we offer a wide variety of Sonicators that are reliable, powerful, and proven. When you need a trustworthy instrument for tissue homogenization, do what tens of thousands of scientists have done for half a century: rely on a Sonicator.

Product applications

  • DNA / RNA extraction
  • Protein extraction / proteomics
  • Organelle isolation
  • Small molecule extraction / metabolomics
  • Pharmaceutical compound extraction for ADME studies
  • Forensics / toxicology

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Tips & Info for Tissue Homogenization Application

  • Sonicators are for research use only.
  • Sonicators are suitable for use with soft tissues. Hard tissues, such as bone or wood, are not suitable for use with ultrasonic homogenizers and may damage the horn.
  • Very tough, fibrous tissue such as ligament may not be homogenized efficiently using an ultrasonic homogenizer. Should you wish to process such tissue, you may wish to pre-treat with collagenase or a similar protease to soften the tissue.
  • All tissue being processed must be fully immersed in liquid, and the tip of the horn must remain below the liquid surface at all times.
  • Do not over-homogenize! Running for longer than necessary may degrade RNA, denature proteins, and shear DNA.
  • For general best practices, see Best Practices for Ultrasonic Homogenization.

Frequently Asked Questions

For your questions, check out our FAQ page. Still can’t find the answer you need? Send us a message here for a quote request, or here for troubleshooting and repair. Our experts will get back to you in no time.

HAVE A QUESTION ABOUT Tissue Homogenization Application?

Contact Us
Contact an Expert Contact an Expert >
Let us help you select the appropriate Sonicator model and accessory for your application. Call us at 203.426.0101 or
fill out a Contact Form.