Shopping Cart
Domestic orders only.
For international orders, including Canada and Mexico, please call 203.426.0101 or e-mail At present, we can only accept online orders for United States delivery.

Order processing lead times.
Sonicator systems have a 7-10 business day lead time. Probes, tips and general accessories are shipped within 1-3 business days. Selecting an express shipping method does not decrease the lead time but will expedite the actual shipping time once the order leaves our facility. Please contact Customer Service at 203.426.0101 if you would like to check stock and receive a more accurate lead time. Thank you.

Tax exempt sales.
Deliveries to CT and NY will be charged sales tax. If you are tax-exempt and do not wish to pay sales tax, please call us at 203.426.0101.
Virus Isolation and Homogenization
Contact an Expert Contact an Expert >
Let us help you select the appropriate Sonicator model and accessory for your application. Call us at 203.426.0101 or
fill out a Contact Form.

Virus Isolation and Homogenization

After the inoculation of the viral strain of interest into the appropriate host cells, and once incubated under the appropriate conditions, the infected cell culture can be treated with a sonicator - typically for a few minutes - in order to release the viruses from the host cells. This happens thanks to the mechanical disruption of the host cell membranes via the pressure created by the high-frequency sound waves generated by the sonicator. This can be followed by both centrifugation to yield a virus pellet, and purification to remove any remaining contaminants. Should your goals be to homogenize the viral particles themselves, longer, higher-intensity sonication is an efficient means of doing so.

When sonicating different viral samples, it’s worth keeping in mind that different viruses have varying sensitivities to ultrasonic lysis. In other words, the optimal conditions for virus isolation vary depending both on the virus itself and the host cells used. At Qsonica, we offer a wide variety of Sonicators that are reliable, powerful, and proven. Combined with a broad selection of horns, the Sonicator line enables you to process a wide range of volumes with varying ultrasonic intensities. When you need a trustworthy instrument for virus isolation and homogenization, do what tens of thousands of scientists have done for half a century: rely on a Sonicator.

Product applications

  • Vaccine development
  • Diagnostics
  • Antiviral drug development
  • Gene therapy
  • Bioprocessing
  • Agriculture


Tips & Info for Virus Isolation and Homogenization

  • For viral isolation from another sample, follow the suggestions for the type of sample in which they are residing (for instance tissue homogenization or bacterial lysis).
  • Viral capsids are small and tough. If you need to lyse them to extract their nucleic acid contents, using a probe with a small tip at a high amplitude will most efficiently lyse them.
  • Use of a viral lysis buffer will help make virion homogenization much faster and easier. Buffers with low quantities of detergent are recommended to prevent foaming.
  • Whether you are looking to isolate or homogenize the viral particles, do not over-homogenize! Running for longer than necessary may degrade RNA, denature proteins, and shear DNA, or may homogenize virions when you only mean to extract them.
  • For general best practices, see Best Practices for Ultrasonic Homogenization.

Frequently Asked Questions

For your questions, check out our FAQ page. Still can’t find the answer you need? Send us a message here for a quote request, or here for troubleshooting and repair. Our experts will get back to you in no time.

HAVE A QUESTION ABOUT Virus Isolation and Homogenization?

Contact Us
Contact an Expert Contact an Expert >
Let us help you select the appropriate Sonicator model and accessory for your application. Call us at 203.426.0101 or
fill out a Contact Form.